Recent advances in the mathematics and physics of biological growth models
نویسنده
چکیده
In this paper, we address some modelling issues related to biological growth. Our treatment is based on a recently-proposed, general formulation for growth within the context of mixture theory (Journal of the Mechanics and Physics of Solids, 52, 2004, 1595–1625). We aim to enhance this treatment by making it more appropriate for the biophysics of growth in soft tissue, specifically tendon. This involves several modifications to the mathematical formulation to represent the reactions, transport and mechanics, and their interactions. We also reformulate the governing differential equations for reaction-transport to represent the incompressibility constraint on the fluid phase of the tissue. This revision enables a straightforward implementation of numerical stabilisation for the hyperbolic, or advectiondominated, limit. A finite element implementation employing an operator splitting scheme is used to solve the coupled, non-linear partial differential equations that arise from the theory. Motivated by our experimental model, an in vitro scaffold-free engineered tendon formed by self-assembly of tendon fibroblasts (Calve et al., 2004), we solve several numerical examples demonstrating biophysical aspects of tissue growth, and the improved numerical performance of the models.
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تاریخ انتشار 2007